In Qatar, CRC is the most common cancer in men, and the second for women after breast cancer. Since fibroblasts are known to be the predominant cell population in a solid tumor microenvironment, the close interactions between fibroblasts and tumor cells can be a target mechanism to understand tumor progression and design therapeutic strategies. The ability of a tumor to metastasize is dependent upon the host tissue stroma that provides the necessary venue to invade through the blood stream or lymphatic pathway.
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